Frequency of autoantibodies and correlation with HLA-DRB1 genotype in sporadic inclusion body myositis (s-IBM): a population control study

J Neuroimmunol. 2012 Aug 15;249(1-2):66-70. doi: 10.1016/j.jneuroim.2012.04.007. Epub 2012 May 2.


The frequency of myositis-associated and myositis-specific autoantibodies (AAb) was compared in 51 s-IBM patients and a population control group. Non-organ specific AAb (ANA, anti-Ro52, anti-Ro60, anti-La, anti-RNP) but not anti-thyroid peroxidase, anti-tissue transglutaminase or myositis-specific antibodies, were more frequent in s-IBM patients, and 14/51 (27%) had another autoimmune disease (Sjögren's syndrome, thyroiditis, psoriasis, vitiligo). The presence of AAb did not correlate with carriage of HLA-DRB1*0301, but there was a negative correlation between ANA/anti-Ro52 and carriage of HLA-DRB1*1301. The findings in this cohort confirm that patients with sIBM do not show evidence of a muscle-specific humoral immune process but have an increased frequency of non-organ specific AAb and other autoimmune disorders.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Autoantibodies / blood
  • Autoantibodies / genetics*
  • Autoantibodies / immunology*
  • Autoantigens / genetics
  • Autoantigens / immunology
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Genotype
  • HLA-DRB1 Chains / genetics*
  • HLA-DRB1 Chains / immunology
  • Humans
  • Male
  • Middle Aged
  • Myositis, Inclusion Body / blood
  • Myositis, Inclusion Body / genetics*
  • Myositis, Inclusion Body / immunology*
  • Polymerase Chain Reaction


  • Autoantibodies
  • Autoantigens
  • HLA-DRB1 Chains