Pioneer factors in hormone-dependent cancers

Nat Rev Cancer. 2012 May 4;12(6):381-5. doi: 10.1038/nrc3263.

Abstract

Pioneer factors are a special class of transcription factor that can associate with compacted chromatin to facilitate the binding of additional transcription factors. The function of pioneer factors was originally described during development; more recently, they have been implicated in hormone-dependent cancers, such as oestrogen receptor-positive breast cancer and androgen receptor-positive prostate cancer. We discuss the importance of pioneer factors in these specific cancers, the discovery of new putative pioneer factors and the interplay between these proteins in mediating nuclear receptor function in cancer.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Breast Neoplasms / genetics
  • Breast Neoplasms / metabolism
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism
  • Drug Design
  • Female
  • Gene Expression Regulation
  • Hepatocyte Nuclear Factor 3-alpha / genetics
  • Hepatocyte Nuclear Factor 3-alpha / metabolism
  • Hormones / metabolism*
  • Humans
  • Male
  • Neoplasms / genetics
  • Neoplasms / metabolism*
  • Pre-B-Cell Leukemia Transcription Factor 1
  • Prostatic Neoplasms / genetics
  • Prostatic Neoplasms / metabolism
  • Proto-Oncogene Proteins / genetics
  • Proto-Oncogene Proteins / metabolism
  • Receptors, Androgen / metabolism
  • Receptors, Estrogen / metabolism
  • Transcription Factors / genetics*
  • Transcription Factors / metabolism*

Substances

  • DNA-Binding Proteins
  • FOXA1 protein, human
  • Hepatocyte Nuclear Factor 3-alpha
  • Hormones
  • Pre-B-Cell Leukemia Transcription Factor 1
  • Proto-Oncogene Proteins
  • Receptors, Androgen
  • Receptors, Estrogen
  • Transcription Factors
  • pbx1 protein, human