Indoor air pollution-related acute lower respiratory infections and low birthweight: a systematic review

J Trop Pediatr. 2012 Dec;58(6):457-66. doi: 10.1093/tropej/fms017. Epub 2012 May 2.


Background: Present study is a systematic review conducted to establish a quantitative association between acute lower respiratory infection (ALRI) and low birthweight (LBW) attributable to Indoor air pollution (IAP) in under-5 children.

Materials and methods: Total of 24 articles for ALRI in under-5 and seven articles for LBW were included in this review. Meta-analysis was done on nine and six articles on ALRI and LBW children, respectively.

Results: Sixteen studies reported significantly elevated odds ratio (range: 1.38-6.0) of ALRI exposed to IAP. Similarly, significantly increased risk of LBW due to IAP was reported in the studies (range: 1.1-1.86). The risk of ALRI increased by 2.51 times, while the risk of LBW increased by 1.45 times due to IAP exposure.

Conclusions: This review of ALRI and LBW attributable by IAP confirms and strengthens the findings of previous reviews and provides further strong evidence of associations of ALRI and LBW with IAP.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Acute Disease
  • Air Pollution, Indoor / adverse effects*
  • Female
  • Humans
  • Infant, Low Birth Weight*
  • Infant, Newborn
  • Respiratory Tract Infections / etiology*
  • Risk Assessment*
  • Risk Factors
  • Smoke / adverse effects*


  • Smoke