⁹⁹mTc-RBC Scintigraphy for diagnosis of intestinal stromal tumor hemorrhage: a case report

Int J Clin Exp Pathol. 2012;5(3):270-3. Epub 2012 Mar 25.


Background: Gastrointestinal stromal tumors (GISTs) are rare and our understanding of the natural history and optimal treatment of GISTs are continually evolving. They are characterized by a remarkable cellular variability and their malignant potential is sometimes difficult to predict.

Case presentation: We report the case of intestinal stromal tumor in a 44 years old patient with a long history of anemia and recurrent hemafecia. By using (99m)Tc-labeled red blood cell ((99m)Tc-RBC) scintigraphy, extensive tracer accumulation in the jejunum was detected. Immunohistochemically, the tumor strongly expresses the KIT (CD117) protein. The intestinal tumor was successfully resected with a postoperative favorable outcome.

Conclusion: (99m)Tc-RBC scintigraphy is an established technique for the identification and localization of gastrointestinal bleeding. Abdominal scintigraphy appears to be a valuable supplement to conventional diagnostic methods for the diagnosis of gastrointestinal stromal tumor hemorrhage.

Keywords: 99mTc-RBC; abdominal; gastrointestinal stromal tumors; scintigraphy.

Publication types

  • Case Reports

MeSH terms

  • Abdominal Pain / etiology
  • Adult
  • Biomarkers, Tumor / analysis
  • Biopsy
  • Erythrocytes / diagnostic imaging*
  • Female
  • Gastrointestinal Hemorrhage / diagnostic imaging*
  • Gastrointestinal Hemorrhage / etiology
  • Gastrointestinal Stromal Tumors / chemistry
  • Gastrointestinal Stromal Tumors / complications
  • Gastrointestinal Stromal Tumors / diagnostic imaging*
  • Gastrointestinal Stromal Tumors / surgery
  • Humans
  • Immunohistochemistry
  • Jejunal Neoplasms / chemistry
  • Jejunal Neoplasms / complications
  • Jejunal Neoplasms / diagnostic imaging*
  • Jejunal Neoplasms / surgery
  • Predictive Value of Tests
  • Proto-Oncogene Proteins c-kit / analysis
  • Radionuclide Imaging
  • Technetium*
  • Treatment Outcome


  • Biomarkers, Tumor
  • Technetium
  • Proto-Oncogene Proteins c-kit