Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 2 (12), 569-75

High Fiber Probiotic Fermented Mare's Milk Reduces the Toxic Effects of Mercury in Rats

Affiliations

High Fiber Probiotic Fermented Mare's Milk Reduces the Toxic Effects of Mercury in Rats

Ahmed M Abdel-Salam et al. N Am J Med Sci.

Abstract

Background: Since the advent of the Industrial Revolution in the late 19th century, we have all been unfortunately exposed to an increasingly toxic and polluted world. Among the most dangerous of these pollutants is mercury, which is considered to be the most toxic non-radioactive heavy metal. Fermented foods may help cleanse the body of heavy metals. Fermentation breaks down the nutrients in foods by the action of beneficial microorganisms and creates natural chelators that are available to bind toxins and remove them from the body.

Aims: The current study was designed to determine the impact of feeding a high fiber probiotic fermented mare's milk on the biological effects of mercury toxicity in rat model.

Methods and materials: The high fiber fermented mare's milk containing probiotics was prepared and its sensory properties, chemical composition, and antioxidant activity were determined. A rat model of mercury toxicity was used. The effect of feeding the high fiber probiotic fermented mare's milk to rats, along with mercury ingestion, was determined by the analysis of several biochemical markers in serum and histopathological examinations of brain and kidney.

Results: The high fiber fermented mare's milk containing probiotics was found to be acceptable by all test panels and volunteers. Mercury ingestion was found to cause biochemical and histopathological alterations in rat serum and tissues. The mercury-treated rats showed a decrease in body weight and an increase in kidney weight. Sera of the mercury treated rats showed alterations in biochemical parameters, and histopathological changes in brain and kidney. However, the rats fed high fiber fermented mare`s milk along with mercury ingestion showed improved histopathology of kidney and brain, and there was restoration of the biochemical parameters in serum to almost normal values.

Conclusions: Feeding high fiber fermented mare`s milk may reduce the toxic effects of mercury.

Keywords: Mare's milk; high-fiber probiotic from fermented mare's milk; mercury contamination.

Similar articles

See all similar articles

Cited by 4 PubMed Central articles

References

    1. Emanuelli T, Rocha JB, Pereira ME, et al. Effect of mercuric chloride intoxication and dimercaprol treatment on delta-aminolevulinate dehydratase from brain, liver and kidney of adult mice. Pharmacol Toxicol. 1996;79:136–143. - PubMed
    1. Shigematsu J, Yasuda T, Goto Y, Tanaka K, Tobimatsu S, Kato M. Recovery of brain dysfunction after methylmercury exposure in rats. J Neurol Sci. 2000;182:61–68. - PubMed
    1. Rocha JB, Rocha LK, Emanuelli T, Pereira ME. Effect of mercuric chloride and lead acetate treatment during the second stage of rapid post-natal brain growth on the behavioral response to chlorpromazine and on delta-ALA-D activity in weaning rats. Toxicol Lett. 2001;125:143–150. - PubMed
    1. Peixoto NC, Pereira ME. Effectiveness of ZnCl2 in protecting against nephrotoxicity induced by HgCl2 in newborn rats. Ecotoxicol Environ Saf. 2007;66:441–446. - PubMed
    1. Magos L, Webb M, Butler WH. The effect of cadmium pretreatment on the nephrotoxic action and kidney uptake of mercury in male and female rats. Br J Exp Pathol. 1974;55:589–594. - PMC - PubMed
Feedback