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Review
, 2 (3), 324-9

Ebolavirus Vaccines for Humans and Apes

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Review

Ebolavirus Vaccines for Humans and Apes

Hugues Fausther-Bovendo et al. Curr Opin Virol.

Abstract

Because of high case fatality proportions, person-to-person transmission, and potential use in bioterrorism, the development of a vaccine against ebolavirus remains a top priority. Although no licensed vaccine or treatment against ebolavirus is currently available, progress in preclinical testing of countermeasures has been made. Here, we will review ebolavirus vaccine candidates and considerations for their use in humans and wild apes.

Figures

Figure 1
Figure 1. Impact of vaccination of bats or apes on human Ebola outbreaks
A-Vaccination of apes could prevent human outbreaks caused by NHPs to human transmission but is associated with logistical and ethical challenges. An alternative approach would be to vaccinate bats to protect both humans and wild apes from ebolavirus outbreaks. B-Unlike strategies for apes that would need to be vaccinated individually, broad-based bat immunization could be achieved through the use of carrier bats whereby (1) bats are captured and a vaseline formulation containing the Ebola vaccine is applied prior to release. (2) Close contact between carrier bats and other bats in the targeted colony results in (3) spreading of the vaccine which is then ingested when bats clean themselves.

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