NuRD and pluripotency: a complex balancing act

Cell Stem Cell. 2012 May 4;10(5):497-503. doi: 10.1016/j.stem.2012.04.011.

Abstract

Embryonic stem cells (ESCs) are defined by two essential features--pluripotency and self-renewal--whose balance requires the concerted action of signal transduction pathways, transcription factor networks, and epigenetic regulators. Recent findings have implicated the NuRD chromatin remodeling complex in the sophisticated choreography of ESC regulatory pathways.

Publication types

  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Chromatin Assembly and Disassembly*
  • Embryonic Stem Cells / physiology*
  • Gene Expression Regulation, Developmental
  • Humans
  • Mi-2 Nucleosome Remodeling and Deacetylase Complex / metabolism*
  • Pluripotent Stem Cells / physiology*
  • Signal Transduction

Substances

  • Mi-2 Nucleosome Remodeling and Deacetylase Complex