Dapsone in the management of autoimmune bullous diseases

Immunol Allergy Clin North Am. 2012 May;32(2):317-22, vii. doi: 10.1016/j.iac.2012.04.011. Epub 2012 Apr 18.

Abstract

Dapsone is used in the treatment of autoimmune bullous diseases (AIBD), a group of disorders resulting from autoimmunity directed against basement membrane and/or intercellular adhesion molecules on cutaneous and mucosal surfaces. This review summarizes the limited published data evaluating dapsone as a therapy for AIBD.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Agranulocytosis / etiology
  • Animals
  • Autoimmune Diseases / drug therapy*
  • Autoimmune Diseases / immunology
  • Dapsone / adverse effects
  • Dapsone / chemistry
  • Dapsone / therapeutic use*
  • Disease Management
  • Drug Hypersensitivity / etiology
  • Humans
  • Leprostatic Agents / therapeutic use*
  • Methemoglobinemia / etiology
  • Neutrophil Activation / drug effects
  • Neutrophils / drug effects
  • Neutrophils / immunology
  • Skin Diseases, Vesiculobullous / drug therapy*
  • Skin Diseases, Vesiculobullous / immunology

Substances

  • Leprostatic Agents
  • Dapsone