Fortifying the link between SIRT1, resveratrol, and mitochondrial function

Cell Metab. 2012 May 2;15(5):566-7. doi: 10.1016/j.cmet.2012.04.016.


The molecular mechanisms behind the health benefits of resveratrol remain enigmatic and controversial. In this issue of Cell Metabolism, Price et al. establish a clear chemical-genetic connection between SIRT1 and resveratrol, providing strong evidence that SIRT1 is critical for resveratrol to stimulate mitochondrial biogenesis and a switch toward oxidative muscle fibers (Price et al., 2012).

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