The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance

Cell Metab. 2012 May 2;15(5):570-3. doi: 10.1016/j.cmet.2012.03.004.


Excessive deposition of fat in the liver (hepatic steatosis) is frequently accompanied by hepatic insulin resistance. Whether this correlation is due to a causal relationship between the conditions has been the subject of considerable debate, and the literature abounds with conflicting data and theories. Here we provide a perspective by defining the problem and its challenges, analyzing the possible causative relationships, and drawing some conclusions.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Fatty Liver / metabolism*
  • Humans
  • Insulin / metabolism*
  • Insulin Resistance / physiology*
  • Liver / metabolism*
  • Mice


  • Insulin