Effects of contrast material on the metabolite ratios in single-voxel MR Spectroscopy of intraaxial brain tumors

Med Hypotheses. 2012 Aug;79(2):129-31. doi: 10.1016/j.mehy.2012.03.029. Epub 2012 May 4.


Aim: The purpose of our study was to determine whether the administration of contrast material affects the results of MR Spectroscopy (MRS) in different intraaxial brain tumors.

Materials and methods: Thirty-three patients (median range 46.72 ± 2.95, range 9-77) with intraaxial brain tumors underwent MRS before and 5 min after intravenous administration of gadolinium based contrast material at the standard dose of 0.1 mmol/kg (Gadodiamide or Gd-DOTA). Metabolite ratios (N-acetyl aspartate (NAA)/Creatine (Cr), Choline (Cho)/Cr, and NAA/Cho) were calculated.

Results: There was no significant difference between the pre and postcontrast MRS spectra as regards to NAA/Cr (p:0.4), Cho/Cr (p:0.2), and NAA/Cho (p:0.2) ratios obtained from the intraaxial brain tumors.

Conclusion: Contrast material administration did not change the metabolite ratios of MRS. Contrast administration would be useful in guiding voxel localization in MRS evaluation of intraaxial brain tumors.

Publication types

  • Clinical Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Artifacts*
  • Biomarkers, Tumor / analysis*
  • Brain / drug effects
  • Brain / metabolism*
  • Brain Neoplasms / metabolism*
  • Child
  • Contrast Media / adverse effects
  • Female
  • Gadolinium DTPA / adverse effects*
  • Humans
  • Magnetic Resonance Spectroscopy / methods*
  • Male
  • Middle Aged
  • Neoplasm Proteins / analysis*
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Young Adult


  • Biomarkers, Tumor
  • Contrast Media
  • Neoplasm Proteins
  • gadodiamide
  • Gadolinium DTPA