Enhanced intrinsic radiosensitivity after treatment with stereotactic radiosurgery for an acoustic neuroma

Radiother Oncol. 2012 Jun;103(3):410-4. doi: 10.1016/j.radonc.2012.03.011. Epub 2012 May 3.


Enhanced radiosensitivity is an uncommon phenomenon attributable to deficient DNA repair after radiotherapy which can be assessed with the γ-H2AX assay. Reports of radiosensitivity after stereotactic radiosurgery (SRS) are uncommon. We describe a case where the clinical, radiological and laboratory findings suggest enhanced radiosensitivity after SRS for an acoustic neuroma.

Publication types

  • Research Support, N.I.H., Intramural

MeSH terms

  • Aged
  • Dose-Response Relationship, Radiation
  • Female
  • Histones / metabolism
  • Humans
  • In Vitro Techniques
  • Neuroma, Acoustic / metabolism
  • Neuroma, Acoustic / radiotherapy*
  • Neuroma, Acoustic / surgery*
  • Radiation Tolerance*
  • Radiosurgery*


  • H2AX protein, human
  • Histones