Development of subsquamous high-grade dysplasia and adenocarcinoma after successful radiofrequency ablation of Barrett's esophagus

Gastroenterology. 2012 Sep;143(3):564-566.e1. doi: 10.1053/j.gastro.2012.04.051. Epub 2012 May 3.


Patients with Barrett's esophagus are frequently treated with radiofrequency ablation (RFA). Those that undergo this procedure have a low risk of developing subsquamous intestinal metaplasia, and none have been reported to develop subsquamous dysplasia or cancer. We report the development of subsquamous neoplasia in 3 patients who were treated with RFA for Barrett's esophagus (2 developed adenocarcinoma and 1 developed high-grade dysplasia). The identification of these cases indicates the need for continued surveillance following RFA, even after complete eradication of intestinal metaplasia, and caution for widespread use of ablation, especially in patients with low-risk Barrett's esophagus.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma / pathology*
  • Aged
  • Barrett Esophagus / pathology
  • Barrett Esophagus / surgery*
  • Biopsy
  • Catheter Ablation*
  • Disease Progression
  • Endoscopy, Gastrointestinal
  • Esophageal Neoplasms / pathology*
  • Esophagus / pathology
  • Esophagus / surgery*
  • Humans
  • Metaplasia
  • Middle Aged
  • Precancerous Conditions / pathology
  • Precancerous Conditions / surgery*
  • Time Factors
  • Treatment Outcome