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. 2012 Mar;135(3):422-8.

Alleviation of Metabolic Abnormalities Induced by Excessive Fructose Administration in Wistar Rats by Spirulina Maxima

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Free PMC article

Alleviation of Metabolic Abnormalities Induced by Excessive Fructose Administration in Wistar Rats by Spirulina Maxima

Urmila Jarouliya et al. Indian J Med Res. .
Free PMC article

Abstract

Background & objectives: Diabetes mellitus is a metabolic disorder characterized by hyperglycaemia. Several natural products have been isolated and identified to restore the complications of diabetes. Spirulina maxima is naturally occurring fresh water cyanobacterium, enriched with proteins and essential nutrients. The aim of the study was to determine whether S. maxima could serve as a therapeutic agent to correct metabolic abnormalities induced by excessive fructose administration in Wistar rats.

Methods: Oral administration of 10 per cent fructose solution to Wistar rats (n = 5 in each group) for 30 days resulted in hyperglycaemia and hyperlipidaemia. Aqueous suspension of S. maxima (5 or 10%) was also administered orally once daily for 30 days. The therapeutic potential of the preparation with reference to metformin (500 mg/kg) was assessed by monitoring various biochemical parameters at 10 day intervals during the course of therapy and at the end of 30 days S. maxima administration.

Results: Significant (P<0.001) reductions in blood glucose, lipid profile (triglycerides, cholesterol and LDL, VLDL) and liver function markers (SGPT and SGOT) were recorded along with elevated level of HDL-C at the end of 30 days therapy of 5 or 10 per cent S. maxima aquous extract. Co-administration of S. maxima extract (5 or 10% aqueous) with 10 per cent fructose solution offered a significant protection against fructose induced metabolic abnormalities in Wistar rats.

Interpretation & conclusions: The present findings showed that S. maxima exhibited anti-hyperglycaemic, anti-hyperlipidaemic and hepatoprotective activity in rats fed with fructose. Further studies are needed to understand the mechanisms.

Figures

Fig. 1
Fig. 1
Effect of S. maximaadministration on blood glucose level. SM, Spirulina maxima; CF, continuous fructose. The values expressed as mean ± SE, n=5. P*<0.05, **<0.001 compared to NC group.
Fig. 2
Fig. 2
Effect of S. maximaadministration on triglyceride level. SM, Spirulina maxima; CF, continuous fructose. The values expressed as mean ± SE, n=5. P*<0.05, **<0.001 compared to NC group.
Fig. 3
Fig. 3
Effect of S. maximaadministration on cholesterol level. SM, Spirulina maxima; CF, continuous fructose. The values expressed as mean ± SE, n=5. P*<0.01, **<0.001 compared to NC group.
Fig. 4
Fig. 4
Effect of S. maxima administration on HDL-C, LDL and VLDL levels. SM, Spirulina maxima; CF, continuous fructose. The values expressed as mean SE, n=5. P*<0.05, **<0.001 compared to NC group.
Fig. 5
Fig. 5
Effect of S. maxima administration on body levels. SM, Spirulina maxima; CF, continuous fructose. The values expressed as mean ± SE, n=5. P*<0.05, **<0.001 compared to NC group.
Fig. 6
Fig. 6
Effects of S. maxima administration on serum glutamate pyruvate transaminase (SGPT) activity. SM, Spirulina maxima; CF, continuous fructose. The values expressed as mean ± SE, n=5. P*<0.05, **<0.001 compared to NC group.
Fig. 7
Fig. 7
Effect of S. maxima administration on serum glutamate oxaloacetate transaminase (SGOT) levels. SM, Spirulina maxima; CF, continuous fructose. The values expressed as mean ± SE, n=5. P*<0.05, **<0.001 compared to NC group.

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