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Review
, 17 (15-16), 913-20

DNA Polymerase Beta (Pol β) Inhibitors: A Comprehensive Overview

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Review

DNA Polymerase Beta (Pol β) Inhibitors: A Comprehensive Overview

Khaled H Barakat et al. Drug Discov Today.

Abstract

Base excision repair (BER) is the fundamental pathway responsible for the elimination of damaged DNA bases and repair of DNA single-strand breaks generated spontaneously or produced by DNA-damaging agents. Among the essential enzymes that are required to achieve the BER reaction is DNA polymerase beta (pol β), which has been regarded as a potential therapeutic target. More than 60 pol β-inhibitors have been identified so far; however, most of them are either not potent or not specific enough to become a drug. In this article we compile an essential knowledge base regarding the structures, the modes of inhibition and the activities of these pharmacologically interesting molecules.

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