GPR18 in microglia: implications for the CNS and endocannabinoid system signalling

Br J Pharmacol. 2012 Dec;167(8):1575-82. doi: 10.1111/j.1476-5381.2012.02019.x.

Abstract

A review of what is presently known about the G protein coupled receptor GPR18 in terms of its expression and distribution, pharmacology and potential implications for central nervous system and endocannabinoid system signalling. LINKED ARTICLES This article is part of a themed section on Cannabinoids. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2012.167.issue-8.

Publication types

  • Review

MeSH terms

  • Animals
  • Arachidonic Acids / metabolism
  • Endocannabinoids / metabolism
  • Glycine / analogs & derivatives
  • Glycine / metabolism
  • Humans
  • Microglia / metabolism*
  • Neurons / metabolism
  • Receptors, G-Protein-Coupled / metabolism*
  • Signal Transduction

Substances

  • Arachidonic Acids
  • Endocannabinoids
  • GPR18 protein, human
  • N-arachidonylglycine
  • Receptors, G-Protein-Coupled
  • Glycine