Glucose administration attenuates spatial memory deficits induced by chronic low-power-density microwave exposure

Physiol Behav. 2012 Jul 16;106(5):631-7. doi: 10.1016/j.physbeh.2012.04.019. Epub 2012 Apr 28.


Extensive evidence indicates that glucose administration attenuates memory deficits in rodents and humans, and cognitive impairment has been associated with reduced glucose metabolism and uptake in certain brain regions including the hippocampus. In the present study, we investigated whether glucose treatment attenuated memory deficits caused by chronic low-power-density microwave (MW) exposure, and the effect of MW exposure on hippocampal glucose uptake. We exposed Wistar rats to 2.45 GHz pulsed MW irradiation at a power density of 1 mW/cm(2) for 3 h/day, for up to 30 days. MW exposure induced spatial learning and memory impairments in rats. Hippocampal glucose uptake was also reduced by MW exposure in the absence or presence of insulin, but the levels of blood glucose and insulin were not affected. However, these spatial memory deficits were reversed by systemic glucose treatment. Our results indicate that glucose administration attenuates the spatial memory deficits induced by chronic low-power-density MW exposure, and reduced hippocampal glucose uptake may be associated with cognitive impairment caused by MW exposure.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analysis of Variance
  • Animals
  • Blood Glucose / radiation effects
  • Dose-Response Relationship, Radiation
  • Glucose / administration & dosage*
  • Glucose / metabolism
  • Hippocampus / metabolism
  • Hippocampus / radiation effects
  • In Vitro Techniques
  • Insulin / metabolism
  • Male
  • Maze Learning / drug effects
  • Maze Learning / radiation effects
  • Memory Disorders / drug therapy*
  • Memory Disorders / etiology*
  • Memory Disorders / pathology
  • Microwaves / adverse effects*
  • Rats
  • Rats, Wistar
  • Reaction Time / drug effects
  • Reaction Time / radiation effects
  • Sweetening Agents / administration & dosage*
  • Time Factors


  • Blood Glucose
  • Insulin
  • Sweetening Agents
  • Glucose