Age-related aneuploidy through cohesion exhaustion

EMBO Rep. 2012 Jun 1;13(6):539-46. doi: 10.1038/embor.2012.54.

Abstract

The trend of women to become pregnant when older than in previous generations poses a paramount medical problem, for oocytes are particularly prone to chromosome missegregation, and aneuploidy increases with age. Recent data strongly suggest that as oocyte age increases sister chromatid cohesion is weakened or lost. Cohesin deterioration seems to contribute significantly to age-dependent aneuploidy, as discussed in this review.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Age Factors
  • Aging
  • Aneuploidy*
  • Animals
  • Cell Cycle Proteins / metabolism
  • Cell Cycle Proteins / physiology
  • Chromosomal Proteins, Non-Histone / metabolism
  • Chromosomal Proteins, Non-Histone / physiology
  • Chromosome Segregation*
  • Humans
  • Meiosis
  • Oocytes / physiology
  • Oogenesis / genetics

Substances

  • Cell Cycle Proteins
  • Chromosomal Proteins, Non-Histone
  • cohesins