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Review
. 2012;2012:756357.
doi: 10.1100/2012/756357. Epub 2012 Apr 1.

A Review: Inflammatory Process in Alzheimer's Disease, Role of Cytokines

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Free PMC article
Review

A Review: Inflammatory Process in Alzheimer's Disease, Role of Cytokines

Jose Miguel Rubio-Perez et al. ScientificWorldJournal. .
Free PMC article

Abstract

Alzheimer's disease (AD) is the most common neurodegenerative disorder to date. Neuropathological hallmarks are β-amyloid (Aβ) plaques and neurofibrillary tangles, but the inflammatory process has a fundamental role in the pathogenesis of AD. Inflammatory components related to AD neuroinflammation include brain cells such as microglia and astrocytes, the complement system, as well as cytokines and chemokines. Cytokines play a key role in inflammatory and anti-inflammatory processes in AD. An important factor in the onset of inflammatory process is the overexpression of interleukin (IL)-1, which produces many reactions in a vicious circle that cause dysfunction and neuronal death. Other important cytokines in neuroinflammation are IL-6 and tumor necrosis factor (TNF)-α. By contrast, other cytokines such as IL-1 receptor antagonist (IL-1ra), IL-4, IL-10, and transforming growth factor (TGF)-β can suppress both proinflammatory cytokine production and their action, subsequently protecting the brain. It has been observed in epidemiological studies that treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) decreases the risk for developing AD. Unfortunately, clinical trials of NSAIDs in AD patients have not been very fruitful. Proinflammatory responses may be countered through polyphenols. Supplementation of these natural compounds may provide a new therapeutic line of approach to this brain disorder.

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References

    1. Alzheimer A. Uber eine eigenartige Erkangkung der Hirnrinde (An unusual illness of the cerebral cortex) Allgemeine Zeitschr Psychisch-Gerichtliche Medizin. 1907;64:146–148.
    1. Hebert LE, Scherr PA, Bienias JL, Bennett DA, Evans DA. Alzheimer disease in the US population: prevalence estimates using the 2000 census. Archives of Neurology. 2003;60(8):1119–1122. - PubMed
    1. Wimo A, Jonsson L, Winblad B. An estimate of the worldwide prevalence and direct costs of dementia in 2003. Dementia and Geriatric Cognitive Disorders. 2006;21(3):175–181. - PubMed
    1. Joachim CL, Selkoe DJ. The seminal role of β-amyloid in the pathogenesis of Alzheimer disease. Alzheimer Disease and Associated Disorders. 1992;6(1):7–34. - PubMed
    1. Löffler J, Huber G. β-Amyloid precursor protein isoforms in various rat brain regions and during brain development. Journal of Neurochemistry. 1992;59(4):1316–1324. - PubMed

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