The multifaceted roles of Eph/ephrin signaling in breast cancer

Cell Adh Migr. Mar-Apr 2012;6(2):138-47. doi: 10.4161/cam.20154. Epub 2012 Mar 1.


Eph receptors and their membrane-bound ligands are intimately involved in the control of morphogenic processes during embryonic development and adult tissue homeostasis. By their ability to orchestrate cell migration, pattern formation and tissue integrity they are also prone to be involved in carcinogenic growth. In this review we concentrate on their involvement in the normal and carcinogenic development of the breast. In this context we summarize their multi-faceted functions as tumor suppressors, tumor promoters, angiogenic inducers and regulators of stem cell homeostasis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Breast Neoplasms / genetics
  • Breast Neoplasms / metabolism*
  • Ephrins / genetics
  • Ephrins / metabolism*
  • Female
  • Humans
  • Models, Biological
  • Receptors, Eph Family / genetics
  • Receptors, Eph Family / metabolism*
  • Signal Transduction / genetics
  • Signal Transduction / physiology


  • Ephrins
  • Receptors, Eph Family