Downregulation of tumor suppressor QKI in gastric cancer and its implication in cancer prognosis

Biochem Biophys Res Commun. 2012 May 25;422(1):187-93. doi: 10.1016/j.bbrc.2012.04.138. Epub 2012 Apr 30.

Abstract

Gastric cancer (GC) is the fourth most common cancer and second leading cause of cancer-related death worldwide. RNA-binding protein Quaking (QKI) is a newly identified tumor suppressor in multiple cancers, while its role in GC is largely unknown. Our study here aimed to clarify the relationship between QKI expression with the clinicopathologic characteristics and the prognosis of GC. In the 222 GC patients' specimens, QKI expression was found to be significantly decreased in most of the GC tissues, which was largely due to promoter hypermethylation. QKI overexpression reduced the proliferation ability of GC cell line in vitro study. In addition, the reduced QKI expression correlated well with poor differentiation status, depth of invasion, gastric lymph node metastasis, distant metastasis, advanced TNM stage, and poor survival. Multivariate analysis showed QKI expression was an independent prognostic factor for patient survival.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Cell Proliferation
  • DNA Methylation
  • Down-Regulation
  • Female
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Lymphatic Metastasis
  • Male
  • Middle Aged
  • Neoplasm Metastasis
  • Prognosis
  • Promoter Regions, Genetic
  • RNA, Messenger / biosynthesis
  • RNA-Binding Proteins / genetics*
  • Stomach Neoplasms / genetics*
  • Stomach Neoplasms / mortality*
  • Stomach Neoplasms / pathology
  • Tumor Cells, Cultured
  • Tumor Suppressor Proteins / genetics*

Substances

  • QKI protein, human
  • RNA, Messenger
  • RNA-Binding Proteins
  • Tumor Suppressor Proteins