Insights into the Plasmodium falciparum schizont phospho-proteome

Microbes Infect. 2012 Aug;14(10):811-9. doi: 10.1016/j.micinf.2012.04.008. Epub 2012 May 5.


It is becoming clear that, as is the case with many human diseases, targeting protein phosphorylation in strategies aimed at developing the next generation of anti-malarials is likely to bear considerable fruit. A major barrier to this development, however, is the paucity of information regarding the role of protein phosphorylation in malaria. A major step has recently been taken in this area with the publication of the first analyses of the phospho-proteome of the most virulent species of human malaria Plasmodium falciparum. Here, we discuss these studies.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Phosphoproteins / analysis*
  • Plasmodium falciparum / chemistry*
  • Plasmodium falciparum / physiology
  • Proteome / analysis*
  • Protozoan Proteins / analysis*
  • Schizonts / chemistry*
  • Schizonts / physiology
  • Signal Transduction


  • Phosphoproteins
  • Proteome
  • Protozoan Proteins