Decreased uptake and binding of 11C-nicotine in brain of Alzheimer patients as visualized by positron emission tomography

J Neural Transm Park Dis Dement Sect. 1990;2(3):215-24. doi: 10.1007/BF02257652.


Positron emission tomography of the brain following intravenous injection of (+) (R) and (-) (S) N-[11C-methyl]nicotine showed a marked reduced uptake of both isomers, especially the (R) form, in Alzheimer patients as compared to age-matched controls. The significantly larger difference between the uptake values of the (S)- and (R)-enantiomers of 11C-nicotine in Azheimer brains may be of diagnostic value.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Alzheimer Disease / diagnostic imaging
  • Alzheimer Disease / metabolism*
  • Brain / diagnostic imaging
  • Brain / metabolism*
  • Carbon Radioisotopes
  • Humans
  • Middle Aged
  • Nicotine / pharmacokinetics*
  • Stereoisomerism
  • Tomography, Emission-Computed


  • Carbon Radioisotopes
  • Nicotine