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Randomized Controlled Trial
. 2012 May;53(2):131-5.
doi: 10.1111/j.1440-0960.2012.00877.x. Epub 2012 Mar 8.

The Evaluation of the Clinical Effect of Topical St Johns Wort (Hypericum Perforatum L.) in Plaque Type Psoriasis Vulgaris: A Pilot Study

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Randomized Controlled Trial

The Evaluation of the Clinical Effect of Topical St Johns Wort (Hypericum Perforatum L.) in Plaque Type Psoriasis Vulgaris: A Pilot Study

Parvaneh Najafizadeh et al. Australas J Dermatol. .

Abstract

In this case series, ten patients with plaque-type psoriasis were treated with Hypericum perforatum ointment. The hypericum ointment was applied to one side of each patient's body and the vehicle to the opposite side twice daily for 4 weeks in a single blinded manner. Modified psoriasis area severity index (PASI) scores were significantly lowered where the formulated ointment had been applied. In determining PASI scores, three factors, erythema, scaling and thickness, were evaluated; all were significantly lower where the formulated ointment had been applied (P = 0.01, P = 0.004, P = 0.04). Hypericum perforatum ointment applied twice daily may be effective in reducing PASI scores in mild plaque-type psoriasis, however, further larger studies need be conducted to achieve a more conclusive result.

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