Gut-associated Microbes of Drosophila Melanogaster

Gut Microbes. Jul-Aug 2012;3(4):307-21. doi: 10.4161/gmic.19896. Epub 2012 May 10.

Abstract

There is growing interest in using Drosophila melanogaster to elucidate mechanisms that underlie the complex relationships between a host and its microbiota. In addition to the many genetic resources and tools Drosophila provides, its associated microbiota is relatively simple (1-30 taxa), in contrast to the complex diversity associated with vertebrates (> 500 taxa). These attributes highlight the potential of this system to dissect the complex cellular and molecular interactions that occur between a host and its microbiota. In this review, we summarize what is known regarding the composition of gut-associated microbes of Drosophila and their impact on host physiology. We also discuss these interactions in the context of their natural history and ecology and describe some recent insights into mechanisms by which Drosophila and its gut microbiota interact.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Drosophila melanogaster / microbiology*
  • Drosophila melanogaster / physiology*
  • Gastrointestinal Tract / microbiology
  • Metagenome*