Abstract
Bioresponsive polymeric nanoparticles have been extensively pursued for the development of tumor-targeted drug delivery. A novel redox-sensitive biodegradable polymer with "trimethyl-locked" benzoquinone was synthesized for the preparation of paclitaxel-incorporated nanoparticles. The synthesized redox-sensitive nanoparticles released paclitaxel in response to chemically triggered reduction.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry*
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Antineoplastic Agents, Phytogenic / pharmacology
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Benzoquinones / chemical synthesis
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Benzoquinones / chemistry*
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Benzoquinones / pharmacology
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Drug Delivery Systems*
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Hydrogen-Ion Concentration
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Oxidation-Reduction
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Paclitaxel / chemical synthesis*
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Paclitaxel / chemistry
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Paclitaxel / pharmacology*
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Polyethylene Glycols / chemistry
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Polyethylene Glycols / pharmacology
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Polymers / chemistry*
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Polymers / pharmacology
Substances
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Antineoplastic Agents, Phytogenic
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Benzoquinones
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Polymers
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Polyethylene Glycols
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Paclitaxel