The impact of hormone therapy on vocal quality in postmenopausal women

J Voice. 2012 Sep;26(5):671.e1-7. doi: 10.1016/j.jvoice.2011.11.011. Epub 2012 May 11.


Objectives: The main purpose of this study was to investigate the impact of hormone therapy (HT) on vocal characteristics in postmenopausal women by comparing postmenopausal women with HT (n=59) and postmenopausal women without HT (n=46). The second purpose was to investigate the differences in vocal characteristics between two types of HT: estrogen therapy (ET) and estrogen-progestogen therapy (E-PT).

Methods: To determine the vocal characteristics in both groups, objective (aerodynamic measurements, vocal range measurements, acoustic analysis, and a determination of the dysphonia severity index) and subjective assessment techniques (perceptual evaluation, videostroboscopic evaluation, and voice handicap index) were used.

Results: The postmenopausal women without HT showed a significantly lower speaking fundamental frequency and were able to phonate lower compared with postmenopausal women with HT. No differences in vocal characteristics were found between postmenopausal women with ET and postmenopausal women with E-PT.

Conclusion: HT seems to counteract the vocal changes caused by menopause. The type of HT did not affect the outcome in this study.

Publication types

  • Comparative Study

MeSH terms

  • Acoustics
  • Chi-Square Distribution
  • Cross-Sectional Studies
  • Disability Evaluation
  • Estradiol / administration & dosage*
  • Estrogen Replacement Therapy*
  • Female
  • Humans
  • Middle Aged
  • Phonation / drug effects
  • Postmenopause*
  • Predictive Value of Tests
  • Progesterone / administration & dosage*
  • Progesterone Congeners / administration & dosage*
  • Severity of Illness Index
  • Speech Acoustics
  • Speech Production Measurement
  • Stroboscopy
  • Video Recording
  • Voice Disorders / diagnosis
  • Voice Disorders / etiology
  • Voice Disorders / physiopathology*
  • Voice Quality / drug effects*


  • Progesterone Congeners
  • Progesterone
  • Estradiol