Network medicine strikes a blow against breast cancer

Cell. 2012 May 11;149(4):731-3. doi: 10.1016/j.cell.2012.04.014.


Drug development for complex diseases is shifting from targeting individual proteins or genes to systems-based attacks targeting dynamic network states. Lee et al. now reveal how the progressive rewiring of a signaling network over time following EGF receptor inhibition leaves triple-negative breast tumors vulnerable to a second, later hit with DNA-damaging drugs, demonstrating that time- and order-dependent drug combinations can be more efficacious in killing cancer cells.

Publication types

  • Comment
  • Research Support, Non-U.S. Gov't