Increased blood pressure and erythrocyte sodium/lithium countertransport activity are not inherited in diabetic nephropathy

Diabetologia. 1990 Oct;33(10):619-24. doi: 10.1007/BF00400206.


Genetic predisposition to essential hypertension, represented by maximal erythrocyte sodium/lithium countertransport activity, has been suggested as a marker for the risk of developing clinical nephropathy in Type 1 (insulin-dependent) diabetes mellitus. To evaluate this hypothesis we measured arterial blood pressure and maximal sodium/lithium countertransport activity of erythrocytes in 80 parents of 49 Type 1 diabetic patients with clinical nephropathy, 78 parents of 49 normoalbuminuric patients and 17 age-matched non-diabetic individuals. The two diabetic groups were carefully matched. In the two groups of parents blood pressure and cell sodium/lithium countertransport activity showed no significant differences (137/83 vs 133/81 mm Hg and 0.33 vs 0.32 mmol/(1 cells x h) respectively). The proportion of parents who had died or received antihypertensive drugs was similar in the two groups. The patients with Type 1 diabetes had significantly higher sodium/lithium countertransport compared to the 39 non-diabetic control subjects independently of the presence or absence of nephropathy (p less than 0.002). However, patients with nephropathy tended to have higher sodium/lithium countertransport activity than normoalbuminuric patients (0.48 vs 0.41 mmol/(1 cells x h), p = 0.06). We conclude that genetic predispositions to essential hypertension and increased maximal erythrocyte sodium/lithium countertransport activity do not appear to be risk markers for the development of clinical nephropathy in Type 1 diabetic patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiporters*
  • Biological Transport
  • Blood Pressure
  • Carrier Proteins / metabolism
  • Diabetes Mellitus, Type 1 / complications
  • Diabetic Nephropathies / complications*
  • Erythrocyte Membrane / metabolism*
  • Female
  • Humans
  • Hypertension / etiology*
  • Lithium / metabolism*
  • Male
  • Middle Aged
  • Sodium / metabolism*


  • Antiporters
  • Carrier Proteins
  • sodium-lithium countertransporter
  • Lithium
  • Sodium