Sororin is a master regulator of sister chromatid cohesion and separation

Cell Cycle. 2012 Jun 1;11(11):2073-83. doi: 10.4161/cc.20241. Epub 2012 Jun 1.

Abstract

The maintenance of sister chromatid cohesion from S phase to the onset of anaphase relies on a small but evolutionarily conserved protein called Sororin. Sororin is a phosphoprotein and its dynamic localization and function are regulated by protein kinases, such as Cdk1/cyclin B and Erk2. The association of Sororin with chromatin requires cohesin to be preloaded to chromatin and modification of Smc3 during DNA replication. Sororin antagonizes the function of Wapl in cohesin releasing from S to G 2 phase and promotes cohesin release from sister chromatid arms in prophase via interaction with Plk1. This review focuses on progress of the identification and regulation of Sororin during cell cycle; role of post-translational modification on Sororin function; role of Sororin in the maintenance and resolution of sister chromatid cohesion; and finally discusses Sororin's emerging role in cancer and the potential issues that need be addressed in the future.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing / metabolism*
  • Animals
  • CDC2 Protein Kinase / metabolism
  • Carrier Proteins / antagonists & inhibitors
  • Carrier Proteins / metabolism
  • Cell Cycle
  • Cell Cycle Proteins / metabolism*
  • Chromatids / metabolism*
  • Chromosomal Proteins, Non-Histone / metabolism
  • DNA Repair
  • Humans
  • Mitogen-Activated Protein Kinase 1 / metabolism
  • Nuclear Proteins / antagonists & inhibitors
  • Nuclear Proteins / metabolism
  • Proto-Oncogene Proteins / antagonists & inhibitors
  • Proto-Oncogene Proteins / metabolism

Substances

  • Adaptor Proteins, Signal Transducing
  • CDCA5 protein, human
  • Carrier Proteins
  • Cell Cycle Proteins
  • Chromosomal Proteins, Non-Histone
  • Nuclear Proteins
  • Proto-Oncogene Proteins
  • WAPL protein, human
  • cohesins
  • CDC2 Protein Kinase
  • Mitogen-Activated Protein Kinase 1