BLIMP1α, the master regulator of plasma cell differentiation is a tumor supressor gene in B cell lymphomas

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2012 Mar;156(1):1-6. doi: 10.5507/bp.2012.003.


Aims: The aim of this review was to summarize recent knowledge of the structure and function of a transcriptional repressor, B lymphocyte induced maturation protein 1 (BLIMP1) and its participation in the pathogenesis of B lymphomas.

Methods and results: This review summarizes the structure and function of BLIMP1, its major target genes and its role as a tumour suppressor in B cell lymphomas. We review our recent data implicating the loss of BLIMP1α as an important step in the pathogenesis of the Epstein-Barr virus (EBV) associated B cell lymphomas.

Conclusions: BLIMP1 is a transcriptional repressor essential for the differentiation of germinal centre (GC) B cells to plasma cells. The loss of BLIMP1 in GC B cells could contribute to the pathogenesis of EBV-associated lymphomas by preventing plasma cell differentiation and viral replication.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Differentiation / genetics*
  • Down-Regulation
  • Gene Expression Regulation, Neoplastic
  • Genes, Tumor Suppressor / physiology*
  • Germinal Center / physiology
  • Herpesvirus 4, Human / physiology
  • Humans
  • Immunoglobulins / biosynthesis
  • Lymphoma, B-Cell / genetics*
  • Lymphoma, B-Cell / virology
  • Plasma Cells / physiology*
  • Positive Regulatory Domain I-Binding Factor 1
  • Repressor Proteins / genetics*
  • Repressor Proteins / physiology


  • Immunoglobulins
  • Repressor Proteins
  • PRDM1 protein, human
  • Positive Regulatory Domain I-Binding Factor 1