Renalase, stroke, and hypertension in hemodialyzed patients

Ren Fail. 2012;34(6):727-31. doi: 10.3109/0886022X.2012.681534. Epub 2012 May 14.


Introduction: Hypertension and kidney disease have been associated with increased incidence of stroke. Renalase, a newly discovered hormone, is secreted by the kidney and circulates in blood. The aim of this study was to assess possible correlations between renalase, blood pressure, stroke, and cardiovascular status in prevalent hemodialyzed patients.

Methods: Renalase was assessed using commercially available assay. Echocardiography was performed in each patient.

Results: Serum renalase was significantly lower in patients with a history of stroke (21%) than in patients without it. Similarly, renalase was significantly lower in hypertensive patients (82%) when compared with normotensives. Serum renalase correlated with creatinine, residual renal function, and transferrin saturation. The only predictor of renalase in multiple regression analysis was the presence of hypertension explaining 90% of the renalase variations.

Conclusions: Our preliminary results suggest that renalase, probably due to the sympathetic nervous system hyperactivity, could be associated with hypertension and cardiovascular complications, including stroke in hemodialyzed patients. However, further studies are needed to establish the possible role of renalase in these complications. Renalase is "a new postulated therapeutic target."

MeSH terms

  • Biomarkers / blood
  • Echocardiography
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Hypertension / blood*
  • Hypertension / complications
  • Kidney Function Tests
  • Male
  • Middle Aged
  • Monoamine Oxidase / blood*
  • Pilot Projects
  • Regression Analysis
  • Renal Dialysis*
  • Statistics, Nonparametric
  • Stroke / blood*
  • Stroke / etiology
  • Transferrin / analysis


  • Biomarkers
  • Transferrin
  • Monoamine Oxidase
  • renalase