The world epidemic of sleep disorders is linked to vitamin D deficiency

Med Hypotheses. 2012 Aug;79(2):132-5. doi: 10.1016/j.mehy.2012.03.031. Epub 2012 May 13.

Abstract

An observation of sleep improvement with vitamin D supplementation led to a 2 year uncontrolled trial of vitamin D supplementation in 1500 patients with neurologic complaints who also had evidence of abnormal sleep. Most patients had improvement in neurologic symptoms and sleep but only through maintaining a narrow range of 25(OH) vitamin D3 blood levels of 60-80 ng/ml. Comparisons of brain regions associated with sleep-wake regulation and vitamin D target neurons in the diencephalon and several brainstem nuclei suggest direct central effects of vitamin D on sleep. We propose the hypothesis that sleep disorders have become epidemic because of widespread vitamin D deficiency. The therapeutic effects together with the anatomic-functional correspondence warrant further investigation and consideration of vitamin D in the etiology and therapy of sleep disorders.

MeSH terms

  • Brain / physiopathology*
  • Causality
  • Comorbidity
  • Global Health
  • Humans
  • Internationality
  • Models, Neurological*
  • Prevalence
  • Sleep Wake Disorders / drug therapy
  • Sleep Wake Disorders / epidemiology*
  • Sleep Wake Disorders / physiopathology*
  • Vitamin D / metabolism*
  • Vitamin D / therapeutic use
  • Vitamin D Deficiency / diet therapy
  • Vitamin D Deficiency / epidemiology*
  • Vitamin D Deficiency / physiopathology*

Substances

  • Vitamin D