The Molecular Biology of Memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB

Mol Brain. 2012 May 14;5:14. doi: 10.1186/1756-6606-5-14.

Abstract

The analysis of the contributions to synaptic plasticity and memory of cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB has recruited the efforts of many laboratories all over the world. These are six key steps in the molecular biological delineation of short-term memory and its conversion to long-term memory for both implicit (procedural) and explicit (declarative) memory. I here first trace the background for the clinical and behavioral studies of implicit memory that made a molecular biology of memory storage possible, and then detail the discovery and early history of these six molecular steps and their roles in explicit memory.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cyclic AMP / metabolism*
  • Cyclic AMP Response Element-Binding Protein / metabolism*
  • Cyclic AMP-Dependent Protein Kinases / metabolism*
  • Humans
  • Memory*
  • RNA-Binding Proteins / metabolism*
  • Response Elements / genetics*

Substances

  • Cyclic AMP Response Element-Binding Protein
  • RNA-Binding Proteins
  • Cyclic AMP
  • Cyclic AMP-Dependent Protein Kinases