BRCT domains: A little more than kin, and less than kind

FEBS Lett. 2012 Aug 14;586(17):2711-6. doi: 10.1016/j.febslet.2012.05.005. Epub 2012 May 11.


BRCT domains are versatile protein modular domains found as single units or as multiple copies in more than 20 different proteins in the human genome. Interestingly, most BRCT-containing proteins function in the same biological process, the DNA damage response network, but show specificity in their molecular interactions. BRCT domains have been found to bind a wide array of ligands from proteins, phosphorylated linear motifs, and DNA. Here we discuss the biology of BRCT domains and how a domain-centric analysis can aid in the understanding of signal transduction events in the DNA damage response network.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Motifs
  • Animals
  • BRCA1 Protein / chemistry*
  • Computer Simulation
  • DNA Damage
  • Genome, Human
  • Humans
  • Ligands
  • Models, Molecular
  • Molecular Conformation
  • Phosphorylation
  • Phylogeny
  • Protein Binding
  • Protein Conformation
  • Protein Structure, Tertiary*
  • Proteins / chemistry*
  • Signal Transduction
  • Static Electricity


  • BRCA1 Protein
  • Ligands
  • Proteins