In vitro activity of TP-271 against Mycobacterium abscessus, Mycobacterium fortuitum, and Nocardia species

Antimicrob Agents Chemother. 2012 Jul;56(7):3986-8. doi: 10.1128/AAC.00743-12. Epub 2012 May 14.


The in vitro activities of TP-271, a novel fluorocycline antimicrobial, against 22 isolates of Mycobacterium abscessus, 22 isolates of Mycobacterium fortuitum, and 19 isolates of Nocardia spp. were studied by a microtiter broth dilution method. The MIC(90)s for M. abscessus, M. fortuitum, and Nocardia spp. were 0.5 μg/ml, 0.03 μg/ml, and 8 μg/ml, respectively. TP-271 was significantly more active than the respective control drug in virtually all tests.

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Microbial Sensitivity Tests
  • Mycobacterium / drug effects*
  • Mycobacterium fortuitum / drug effects*
  • Nocardia / drug effects*


  • Anti-Bacterial Agents