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Randomized Controlled Trial
. 2013 Jan;8(1):65-72.
doi: 10.1093/scan/nss054. Epub 2012 May 13.

MBSR vs Aerobic Exercise in Social Anxiety: fMRI of Emotion Regulation of Negative Self-Beliefs

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Free PMC article
Randomized Controlled Trial

MBSR vs Aerobic Exercise in Social Anxiety: fMRI of Emotion Regulation of Negative Self-Beliefs

Philippe Goldin et al. Soc Cogn Affect Neurosci. .
Free PMC article

Abstract

Mindfulness-based stress reduction (MBSR) is thought to reduce emotional reactivity and enhance emotion regulation in patients with social anxiety disorder (SAD). The goal of this study was to examine the neural correlates of deploying attention to regulate responses to negative self-beliefs using functional magnetic resonance imaging. Participants were 56 patients with generalized SAD in a randomized controlled trial who were assigned to MBSR or a comparison aerobic exercise (AE) stress reduction program. Compared to AE, MBSR yielded greater (i) reductions in negative emotion when implementing regulation and (ii) increases in attention-related parietal cortical regions. Meditation practice was associated with decreases in negative emotion and social anxiety symptom severity, and increases in attention-related parietal cortex neural responses when implementing attention regulation of negative self-beliefs. Changes in attention regulation during MBSR may be an important psychological factor that helps to explain how mindfulness meditation training benefits patients with anxiety disorders.

Figures

Fig. 1
Fig. 1
Consolidated standards of reporting trials (CONSORTs) diagram for a RCT of MBSR vs AE.
Fig. 2
Fig. 2
Structure of one autobiographical social situation block with 10 trials embedded.
Fig. 3
Fig. 3
The effect of MBSR and AE on negative emotion ratings when reading neutral statements, reacting and regulating negative self-beliefs. *P < 0.05, **P < 0.005. Error bars = standard error of the mean.
Fig. 4
Fig. 4
Percent reduction in negative emotion during emotion regulation of negative self-beliefs at baseline and post-MBSR and AE. Interaction of Group by Time: F(2,37) = 4.99, P = 0.03, formula image = 0.12. Error bars = standard error of the mean. *P < 0.05
Fig. 5
Fig. 5
BOLD responses for interaction of Group (MBSR, AE) × Time (Pre, Post) for regulate vs react negative self-beliefs contrast. Percent signal change = Change in BOLD signal from pre- to post-intervention. Interaction of Group by Time: F(2,40) ≥ 7.66, P = 0.004, Error bars = standard error of the mean. 1 = Culmen, 2 = Right IPL, 3 = Right SPL, 4 = Left Lingual Gyrus, 5 = Right IPL.

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