Quantification of antiangiogenic and antivascular drug activity by kinetic analysis of DCE-MRI data

Clin Pharmacol Ther. 2012 Jul;92(1):118-24. doi: 10.1038/clpt.2012.63. Epub 2012 May 16.

Abstract

Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) can be used to quantify the response of tumors to vascular targeting agents. Tumor response is frequently assessed using mathematical models that describe the distribution of contrast agents over time as a function of fundamental characteristics of vascular physiology. Generally, mathematical models of biological systems are abstractions that attempt to retain fundamental physiologic characteristics, thereby allowing for multiple potential modeling approaches and structures. Various DCE-MRI modeling techniques are discussed in this article.

Publication types

  • Review

MeSH terms

  • Angiogenesis Inhibitors / pharmacokinetics*
  • Angiogenesis Inhibitors / therapeutic use
  • Contrast Media
  • Humans
  • Image Enhancement / methods
  • Magnetic Resonance Imaging / methods*
  • Mathematical Concepts
  • Models, Biological
  • Neoplasms* / blood supply
  • Neoplasms* / diagnosis
  • Neoplasms* / physiopathology
  • Neovascularization, Pathologic* / diagnosis
  • Neovascularization, Pathologic* / drug therapy
  • Pharmacokinetics
  • Pharmacological Phenomena

Substances

  • Angiogenesis Inhibitors
  • Contrast Media