Abstract
Reduced protective immunity leads to viral persistence and demyelination in Theiler's murine encephalomyelitis. The aim of the present study was to compare the phenotype of brain-infiltrating leukocytes and cytokine expression in susceptible SJL and resistant C57BL/6 mice during Theilervirus-induced acute polioencephalitis. In contrast to C57/BL6 mice, SJL mice show an increased number of Foxp3(+) regulatory T cells and CD45R(+) B cells associated with delayed viral elimination and elevated IL-10 mRNA transcripts in the brain. Results substantiate the hypothesis that an imbalanced cytokine milieu during the early infection phase contributes to ineffective antiviral immunity in animals with a susceptible genetic background.
Copyright © 2012 Elsevier B.V. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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B-Lymphocyte Subsets / immunology
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Brain / immunology*
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Brain / metabolism
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Brain / virology*
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Cardiovirus Infections / immunology*
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Cardiovirus Infections / virology*
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Cytokines / analysis
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Cytokines / biosynthesis
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Disease Models, Animal
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Forkhead Transcription Factors / immunology
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Gene Expression Regulation
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Immunophenotyping
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Interleukin-10 / biosynthesis*
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Interleukin-10 / genetics
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Leukocyte Common Antigens / immunology
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Mice
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Mice, Inbred C57BL
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Multiple Sclerosis / immunology
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Multiple Sclerosis / virology
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RNA, Messenger / analysis
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T-Lymphocyte Subsets / immunology
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T-Lymphocytes, Regulatory / immunology
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Theilovirus
Substances
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Cytokines
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Forkhead Transcription Factors
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Foxp3 protein, mouse
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IL10 protein, mouse
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RNA, Messenger
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Interleukin-10
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Leukocyte Common Antigens