MiR-145 inhibits tumor angiogenesis and growth by N-RAS and VEGF

Cell Cycle. 2012 Jun 1;11(11):2137-45. doi: 10.4161/cc.20598. Epub 2012 Jun 1.


MiR-145 is known as a tumor suppressor in numerous human cancers. However, its role in tumor angiogenesis remains poorly defined. In this study, we found that miR-145 was significantly downregulated in breast cancer tissues by using 106 cases of normal and cancer tissues as well as in breast cancer cells. MiR-145 exhibited inhibitory role in tumor angiogenesis, cell growth and invasion and tumor growth through the post-transcriptional regulation of the novel targets N-RAS and VEGF-A. In addition, we provide evidence that the expression levels of miR-145 correlate inversely with malignancy stages of breast tumors, although there is no association between miR-145 levels and hormone receptor levels in breast cancer. Taken together, these results demonstrate that miR-145 plays important inhibitory role in breast cancer malignancy by targeting N-RAS and VEGF-A, which may be potential therapeutic and diagnostic targets.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Breast Neoplasms / metabolism
  • Breast Neoplasms / pathology
  • Cell Line, Tumor
  • Cell Proliferation
  • Cell Survival
  • Down-Regulation
  • Female
  • Humans
  • Mice
  • MicroRNAs / metabolism*
  • Neovascularization, Pathologic*
  • Transplantation, Heterologous
  • Vascular Endothelial Growth Factor A / metabolism*
  • ras Proteins / metabolism*


  • MIRN145 microRNA, human
  • MicroRNAs
  • Vascular Endothelial Growth Factor A
  • ras Proteins