Engineering biomaterials to integrate and heal: the biocompatibility paradigm shifts

Biotechnol Bioeng. 2012 Aug;109(8):1898-911. doi: 10.1002/bit.24559. Epub 2012 May 24.


This article focuses on one of the major failure routes of implanted medical devices, the foreign body reaction (FBR)--that is, the phagocytic attack and encapsulation by the body of the so-called "biocompatible" biomaterials comprising the devices. We then review strategies currently under development that might lead to biomaterial constructs that will harmoniously heal and integrate into the body. We discuss in detail emerging strategies to inhibit the FBR by engineering biomaterials that elicit more biologically pertinent responses.

Publication types

  • Review

MeSH terms

  • Biocompatible Materials / chemistry*
  • Foreign-Body Reaction / prevention & control*
  • Prostheses and Implants*


  • Biocompatible Materials