The contribution of rodent models to the pathological assessment of flaviviral infections of the central nervous system

Arch Virol. 2012 Aug;157(8):1423-40. doi: 10.1007/s00705-012-1337-4. Epub 2012 May 17.


Members of the genus Flavivirus are responsible for a spectrum of important neurological syndromes in humans and animals. Rodent models have been used extensively to model flavivirus neurological disease, to discover host-pathogen interactions that influence disease outcome, and as surrogates to determine the efficacy and safety of vaccines and therapeutics. In this review, we discuss the current understanding of flavivirus neuroinvasive disease and outline the host, viral and experimental factors that influence the outcome and reliability of virus infection of small-animal models.

Publication types

  • Review

MeSH terms

  • Animals
  • Central Nervous System / virology*
  • Cricetinae
  • Disease Models, Animal*
  • Encephalitis, Viral* / drug therapy
  • Encephalitis, Viral* / prevention & control
  • Encephalitis, Viral* / virology
  • Flavivirus / pathogenicity*
  • Flavivirus Infections* / drug therapy
  • Flavivirus Infections* / prevention & control
  • Flavivirus Infections* / virology
  • Host-Pathogen Interactions
  • Insect Vectors / virology
  • Mice
  • Rodentia*