Adolescent fiber consumption is associated with visceral fat and inflammatory markers

J Clin Endocrinol Metab. 2012 Aug;97(8):E1451-7. doi: 10.1210/jc.2012-1784. Epub 2012 May 16.


Context: The link between adolescent fiber consumption, inflammation, and body fat distribution has not been investigated.

Objective: This study investigated associations of dietary fiber intake with inflammatory-related biomarkers and robust measures of total and central adiposity in a sample of 559 adolescents aged 14-18 yr (49% female, 45% Black).

Methods: Fasting blood samples were measured for leptin, adiponectin, resistin, C-reactive protein, and fibrinogen. Diet was assessed with four to seven 24-h recalls, and physical activity was determined by accelerometry. Fat-free soft tissue mass and fat mass were measured by dual-energy x-ray absorptiometry. Visceral adipose tissue was assessed using magnetic resonance imaging.

Results: Multiple linear regression, adjusting for age, race, Tanner stage, fat-free soft tissue mass, energy intake, and physical activity, revealed that dietary fiber intake was inversely associated with fat mass and serum leptin in males (all P < 0.03) but not in females. In both genders, dietary fiber intake was negatively associated with visceral adipose tissue, plasma C-reactive protein, and plasma fibrinogen and positively associated with plasma adiponectin (all P < 0.05). No relations were found between dietary fiber intake and plasma resistin in either males or females.

Conclusion: Our adolescent data suggest that greater consumption of dietary fiber is associated with lower visceral adiposity and multiple biomarkers implicated in inflammation.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adiponectin / blood
  • Adiposity
  • Adolescent
  • C-Reactive Protein / analysis
  • Cross-Sectional Studies
  • Dietary Fiber / administration & dosage*
  • Female
  • Fibrinogen / analysis
  • Humans
  • Inflammation / prevention & control*
  • Intra-Abdominal Fat / metabolism*
  • Linear Models
  • Male
  • Resistin / blood


  • Adiponectin
  • Dietary Fiber
  • RETN protein, human
  • Resistin
  • Fibrinogen
  • C-Reactive Protein