Prognostic value of indeterminate IFN-γ release assay results in HIV-1 infection

J Clin Microbiol. 2012 Aug;50(8):2767-9. doi: 10.1128/JCM.01054-12. Epub 2012 May 16.


In this prospective, longitudinal study on 948 HIV-1-infected patients, subjects with an indeterminate IFN-γ (gamma interferon) release assay (IGRA) result at baseline were at significantly higher risk of developing AIDS-defining manifestations other than tuberculosis (TB) irrespective of CD4(+) T cell count. Thus, in HIV-1-infected patients with advanced quantitative CD4(+) T cell depletion, an indeterminate IGRA might indicate an additional loss of global T cell function, warranting detailed clinical evaluation and careful follow-up.

Publication types

  • Evaluation Study

MeSH terms

  • AIDS-Related Opportunistic Infections / diagnosis*
  • Adult
  • CD4 Lymphocyte Count
  • Female
  • HIV Infections / complications*
  • HIV Wasting Syndrome / diagnosis*
  • Humans
  • Interferon-gamma Release Tests / methods*
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Prognosis
  • Prospective Studies