Aloe vera has a long history of popular and traditional use. It is used in traditional Indian medicine for constipation, colic, skin diseases, worm infestation, and infections (Heber 2007). It is also used in Trinidad and Tobago for hypertension (Lans 2006) and among Mexican Americans for the treatment of type 2 diabetes mellitus (DM; Coronado et al. 2004). In Chinese medicine, it is often recommended in the treatment of fungal diseases (Heber 2007). In Western society, Aloe vera is one of the few herbal medicines in common usage, and it has found widespread use in the cosmetic, pharmaceutical, and food industries. In the case of health, the therapeutic claims for the topical and oral application of Aloe vera cover a wide range of conditions, but few claims have been the subject of robust clinical investigation. The conditions for which clinical trials of Aloe vera have been conducted include skin conditions, management of burn and wound healing, constipation, DM, and gastrointestinal disorders.
Copyright © 2011 by Taylor and Francis Group, LLC.
- TAXONOMY AND TRADITIONAL ORIGINS
- CURRENT USAGE
- STRUCTURE AND CHEMICAL CONSTITUENTS
- EFFECT OF CULTIVATION AND PROCESSING
- HEALTH EFFECTS: THE SCIENTIFIC EVIDENCE
- ACTIVE INGREDIENTS AND MECHANISMS OF ACTION
- SAFETY AND EFFICACY
- DRUG/VITAMIN BIOAVAILABILITY
- RESEARCH NEEDS
Therapeutic effects of Aloe vera on cutaneous microcirculation and wound healing in second degree burn model in rats.J Med Assoc Thai. 2000 Apr;83(4):417-25. J Med Assoc Thai. 2000. PMID: 10808702
The therapeutic efficacy and properties of topical Aloe vera in thermal burns.J Med Assoc Thai. 2004 Oct;87 Suppl 4:S69-78. J Med Assoc Thai. 2004. PMID: 21213486 Review.
Aloe vera as an herbal medicine in the treatment of metabolic syndrome: A review.Phytother Res. 2019 Oct;33(10):2649-2660. doi: 10.1002/ptr.6465. Epub 2019 Aug 28. Phytother Res. 2019. PMID: 31456283 Review.
Photocarcinogenesis study of aloe vera [CAS NO. 481-72-1(Aloe-emodin)] in SKH-1 mice (simulated solar light and topical application study).Natl Toxicol Program Tech Rep Ser. 2010 Sep;(553):7-33, 35-97, 99-103 passim. Natl Toxicol Program Tech Rep Ser. 2010. PMID: 21031007
Transforming growth factor-β (TGF-β) activation in cutaneous wounds after topical application of aloe vera gel.Can J Physiol Pharmacol. 2016 Dec;94(12):1285-1290. doi: 10.1139/cjpp-2015-0460. Epub 2016 Jul 14. Can J Physiol Pharmacol. 2016. PMID: 27660884