Muscarinic receptor activation facilitates the induction of long-term potentiation (LTP) in the rat dentate gyrus

Neurosci Lett. 1990 Aug 14;116(1-2):34-9. doi: 10.1016/0304-3940(90)90382-j.


Bath application of two different concentrations of muscarine produced two different effects on evoked responses in the dentate gyrus of rat hippocampal slices. A concentration of 1 microM muscarine did not affect the evoked population spike or excitatory postsynaptic potential (EPSP), but facilitated the induction of LTP. In contrast, a concentration of 10 microM muscarine depressed both the population spike and EPSP, but had no effect on LTP induction. The M1 muscarinic receptor antagonist pirenzepine (1 microM) blocked the muscarine-induced facilitation of LTP, but had no effect on the depression of evoked responses. These data suggest that activation of M1 receptors can facilitate the induction of LTP.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Electric Stimulation
  • Evoked Potentials / drug effects
  • Hippocampus / drug effects
  • Hippocampus / physiology*
  • In Vitro Techniques
  • Kinetics
  • Muscarine / pharmacology*
  • Pirenzepine / pharmacology*
  • Rats
  • Receptors, Muscarinic / drug effects
  • Receptors, Muscarinic / physiology*


  • Receptors, Muscarinic
  • Pirenzepine
  • Muscarine