2-Chloroadenosine decreases long-term potentiation in the hippocampal CA1 area of the rat

Neurosci Lett. 1990 Oct 2;118(1):107-11. doi: 10.1016/0304-3940(90)90260-g.

Abstract

The effect of the adenosine (ADO) analogue 2-chloroadenosine (CADO) on frequency-induced long-term potentiation (LTP) of the responses evoked by stimulation of the Schaffer fibres and recorded in CA1 area was studied in hippocampal slices of the rat. CADP significantly decreased LTP of the population spikes (PS) (EC50 = 0.28 microM), and LTP of the field excitatory postsynaptic potentials (f.e.p.s.p) (EC50 = 0.33 microM). These effects were reversed by the ADO receptor antagonist 8-phenyltheophylline (8-PT) (2.5 microM). It is concluded that CADO decreases LTP through activation of a xanthine-sensitive ADO receptor.

MeSH terms

  • 2-Chloroadenosine / antagonists & inhibitors
  • 2-Chloroadenosine / pharmacology
  • Adenosine / antagonists & inhibitors
  • Adenosine / pharmacology
  • Animals
  • Electric Stimulation
  • Electrodes, Implanted
  • Hippocampus / cytology
  • Hippocampus / drug effects
  • Hippocampus / physiology*
  • In Vitro Techniques
  • Rats
  • Rats, Inbred Strains
  • Synapses / drug effects
  • Theophylline / analogs & derivatives
  • Theophylline / pharmacology

Substances

  • 2-Chloroadenosine
  • Theophylline
  • 8-phenyltheophylline
  • Adenosine