Birdshot Retinochoroidopathy Masquerading as Intraocular Lymphoma

Ocul Immunol Inflamm. 2012 Aug;20(4):306-8. doi: 10.3109/09273948.2012.689074. Epub 2012 May 17.

Abstract

We present a case of a patient with bilateral posterior uveitis HLA-A29 positive, masquerading intraocular lymphoma. A 43 year-old woman presented with bilateral vitritis and chorioretinal lesions compatible with "birdshot lesions". The patient was initially diagnosed with birdshot retinochoroidopathy and later on, during follow up, the occurrence of neurologic involvement and the lack of response to systemic immunosuppression led us to re-evaluate the diagnosis. A definite diagnosis of intraocular lymphoma with central nervous system involvement was made. This case is presented to highlight the importance of careful follow-up of patients with chronic uveitis and re-evaluation of systemic symptoms and signs, in particular when ocular findings are highly suggestive for masquerade syndrome.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Adult
  • Antigens, CD19 / analysis
  • Antigens, CD20 / analysis
  • Birdshot Chorioretinopathy
  • Central Nervous System Neoplasms / diagnosis*
  • Central Nervous System Neoplasms / drug therapy
  • Central Nervous System Neoplasms / radiotherapy
  • Chorioretinitis / diagnosis*
  • Chorioretinitis / drug therapy
  • Cyclosporine / therapeutic use
  • Eye Neoplasms / diagnosis*
  • Eye Neoplasms / drug therapy
  • Eye Neoplasms / radiotherapy
  • Fatal Outcome
  • Female
  • HLA-A Antigens / analysis
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Lymphoma, Large B-Cell, Diffuse / diagnosis*
  • Lymphoma, Large B-Cell, Diffuse / drug therapy
  • Lymphoma, Large B-Cell, Diffuse / radiotherapy
  • Mycetoma / diagnosis
  • Prednisone / therapeutic use
  • Visual Acuity

Substances

  • Antigens, CD19
  • Antigens, CD20
  • HLA-A Antigens
  • HLA-A29 antigen
  • Immunosuppressive Agents
  • Cyclosporine
  • Prednisone

Supplementary concepts

  • Birdshot chorioretinopathy