Euthyroid low thyroxine (T4) and triiodothyronine (T3) states in prematures and sick neonates

Pediatr Clin North Am. 1990 Dec;37(6):1297-312. doi: 10.1016/s0031-3955(16)37012-2.


This article reviews the ontogenesis of thyroid system function in the human fetus and newborn and characterizes thyroid function in the premature infant. Thyroid function disorders associated with neonatal adaptation and illness also are reviewed; these include transient hypothyroxinemia, transient primary hypothyroidism, and the syndrome of nonthyroidal illness.

Publication types

  • Review

MeSH terms

  • Embryonic and Fetal Development
  • Euthyroid Sick Syndromes / blood*
  • Fetal Blood
  • Humans
  • Infant, Newborn
  • Infant, Premature, Diseases / blood*
  • Thyroid Gland / physiology
  • Thyroxine / blood*
  • Triiodothyronine / blood*


  • Triiodothyronine
  • Thyroxine