Regional gray matter changes in obsessive-compulsive disorder: relationship to clinical characteristics

Cornelia Exner; Ulrike Zetsche; Vera Martin; Winfried Rief; Andreas Jansen

doi:10.1016/j.pscychresns.2011.10.007

Regional gray matter changes in obsessive-compulsive disorder: relationship to clinical characteristics

Psychiatry Res. 2012 Apr 30;202(1):74-6. doi: 10.1016/j.pscychresns.2011.10.007. Epub 2012 May 16.

Authors

Cornelia Exner¹, Ulrike Zetsche, Vera Martin, Winfried Rief, Andreas Jansen

Affiliation

¹ Department of Clinical Psychology and Psychotherapy, University of Marburg, Marburg, Germany. exnerc@uni-leipzig.de

PMID: 22595507
DOI: 10.1016/j.pscychresns.2011.10.007

Abstract

Regional brain volumes were compared between 23 participants with obsessive-compulsive disorder (OCD) and 36 healthy controls using magnetic resonance imaging with voxel-based morphometry. A volumetric decrease in OCD was found in the right mediofrontal cortex. An increase was found in the left temporoparietal cortex. Volume alterations were related to symptom severity and age of onset.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Brain / pathology*
Female
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Middle Aged
Nerve Fibers, Unmyelinated / pathology*
Neuroimaging
Obsessive-Compulsive Disorder / pathology*
Organ Size