Regional gray matter changes in obsessive-compulsive disorder: relationship to clinical characteristics

Psychiatry Res. 2012 Apr 30;202(1):74-6. doi: 10.1016/j.pscychresns.2011.10.007. Epub 2012 May 16.


Regional brain volumes were compared between 23 participants with obsessive-compulsive disorder (OCD) and 36 healthy controls using magnetic resonance imaging with voxel-based morphometry. A volumetric decrease in OCD was found in the right mediofrontal cortex. An increase was found in the left temporoparietal cortex. Volume alterations were related to symptom severity and age of onset.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Brain / pathology*
  • Female
  • Humans
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Nerve Fibers, Unmyelinated / pathology*
  • Neuroimaging
  • Obsessive-Compulsive Disorder / pathology*
  • Organ Size